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Symbol
Name
ID 		Esr2
estrogen receptor 2 (beta)
MGI:109392
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Leukopenia
Pericarditis
Lymphadenopathy
Hepatosplenomegaly
Helicobacter pylori infection
Lupus nephritis
Nephritis
Abnormality of the immune system
Discoid lupus rash
Malar rash
Serositis
Decreased circulating complement C3 concentration
Decreased circulating complement C4 concentration
Autoimmunity
Anti-citrullinated protein antibody positivity
Antineutrophil antibody positivity
Perinuclear antineutrophil antibody positivity
Antinuclear antibody positivity
Anti-dsDNA antibody positivity
Anti-La/SS-B antibody positivity
Anti-Sm antibody positivity
Anti-U1 ribonucleoprotein antibody positivity
Antiphospholipid antibody positivity
Rheumatoid factor positive
Systemic lupus erythematosus
Disease(s) Associated with ESR2
pre-eclampsia
rheumatoid arthritis
systemic lupus erythematosus

Mouse Phenotypes
immune system phenotype
colitis
enlarged spleen
spleen hyperplasia
abnormal leukopoiesis
abnormal lymphopoiesis
increased pro-B cell number
increased neutrophil cell number
increased granulocyte number
abnormal B cell number
increased pre-B cell number
increased monocyte cell number
increased leukocyte cell number
spleen hypoplasia
enlarged lymph nodes
urinary bladder inflammation
Availability Mouse Genotype
Esr2tm1.2Pcn/Esr2tm1.2Pcn *
Esr2tm1Mma/Esr2tm1Mma
Esr2tm1Unc/Esr2tm1Unc
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory